HeLa cells were subjected to SDS PAGE followed by western blot with FNab06160(PARP9 antibody) at dilution of 1:500
IP Result of anti-PARP9 (IP:FNab06160, 4ug; Detection:FNab06160 1:500) with MCF-7 cells lysate 4000ug.
Immunohistochemistry of paraffin-embedded human spleen using FNab06160(PARP9 antibody) at dilution of 1:50
Background
In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.